Thomas Moore Selected Research

Central Nervous System Cavernous Hemangioma

1/2022	Propranolol as therapy for cerebral cavernous malformations: a cautionary note.
1/2021	Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism in animal models.
1/2021	PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
10/2020	Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.
1/2020	Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu.
1/2019	Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.
1/2018	Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional Growth.
1/2017	RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations.
1/2017	Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.
1/2016	Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease.

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Thomas Moore Research Topics

Disease

11	Central Nervous System Cavernous Hemangioma 01/2022 - 01/2016
9	Hemorrhage 01/2022 - 01/2017
4	Cavernous Hemangioma (Cavernous Angioma) 11/2021 - 01/2019
4	Neoplasms (Cancer) 06/2019 - 02/2013
3	Vascular Malformations 10/2021 - 01/2016
3	Wounds and Injuries (Trauma) 07/2019 - 01/2012
2	Infections 07/2019 - 01/2012
1	Familial cerebral cavernous malformation 06/2022
1	Venous Thrombosis (Deep-Vein Thrombosis) 08/2021
1	Pulmonary Embolism 08/2021
1	Thromboembolism 08/2021
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2021
1	Central Nervous System Diseases (CNS Diseases) 11/2019
1	Surgical Wound Infection 07/2019
1	Inflammation (Inflammations) 01/2018
1	Knee Injuries (Knee Injury) 01/2018
1	Disease Progression 01/2018
1	Idiopathic Pulmonary Fibrosis 10/2017
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 10/2017
1	Breast Neoplasms (Breast Cancer) 01/2017
1	Stroke (Strokes) 01/2017
1	Fatigue 09/2016
1	Hypertension (High Blood Pressure) 01/2016
1	Communicable Diseases (Infectious Diseases) 02/2014
1	Clostridium Infections 02/2014
1	Glioblastoma (Glioblastoma Multiforme) 12/2013
1	Substance-Related Disorders (Drug Abuse) 03/2011
1	Histoplasmosis 04/2007
1	Staphylococcal Infections 08/2006
1	Bacteremia 08/2006
1	Body Weight (Weight, Body) 08/2006
1	Gestational Diabetes (Gestational Diabetes Mellitus) 10/2004

Drug/Important Bio-Agent (IBA)

6	Biomarkers (Surrogate Marker)IBA 01/2022 - 10/2017
4	Proteins (Proteins, Gene)FDA Link 01/2022 - 08/2006
4	IronIBA 01/2021 - 01/2016
4	Pharmaceutical PreparationsIBA 11/2020 - 03/2011
3	Propranolol (Inderal)FDA LinkGeneric 01/2022 - 01/2021
3	Phosphotransferases (Kinase)IBA 01/2021 - 01/2017
3	rho-Associated KinasesIBA 01/2020 - 01/2016
2	MicroRNAs (MicroRNA)IBA 06/2022 - 01/2019
2	Adrenergic Receptors (Adrenergic Receptor)IBA 10/2021 - 01/2021
2	fasudil (AT 877)IBA 01/2019 - 01/2017
2	Simvastatin (Zocor)FDA LinkGeneric 01/2019 - 01/2017
1	Lipopolysaccharide ReceptorsIBA 01/2022
1	Blood Proteins (Serum Proteins)IBA 01/2022
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022
1	vinyltriethoxysilane (VTES)IBA 08/2021
1	Adrenergic Antagonists (Antiadrenergic Agents)IBA 01/2021
1	LipopolysaccharidesIBA 11/2020
1	Versicans (Versican)IBA 10/2020
1	Transcription Factors (Transcription Factor)IBA 10/2020
1	AntibodiesIBA 01/2020
1	Antigen-Antibody Complex (Immune Complex)IBA 01/2020
1	AutoantigensIBA 01/2020
1	Complement System Proteins (Complement)IBA 01/2020
1	Immunoglobulin G (IgG)IBA 01/2020
1	Immunoglobulins (Immunoglobulin)IBA 11/2019
1	Protein Kinase InhibitorsIBA 01/2019
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2017
1	Stainless Steel (Steel, Stainless)IBA 09/2016
1	CholesterolIBA 01/2016
1	Heme (Haem)IBA 01/2016
1	Tumor Biomarkers (Tumor Markers)IBA 01/2014
1	CollagenIBA 12/2013
1	SuspensionsIBA 04/2007
1	posaconazole FDA Link 04/2007
1	Monoclonal AntibodiesIBA 08/2006
1	Anti-Bacterial Agents (Antibiotics)IBA 08/2006
1	factor AIBA 08/2006
1	Glyburide (Glibenclamide)FDA LinkGeneric 10/2004

Therapy/Procedure

8	Therapeutics 01/2022 - 08/2006
2	Length of Stay 07/2019 - 01/2016
2	Drug Therapy (Chemotherapy) 01/2014 - 02/2013
1	Aftercare (After-Treatment) 01/2020
1	Suction (Suction Drainage) 07/2019
1	Blood Transfusion (Blood Transfusions) 07/2019
1	Braces 01/2018
1	Fracture Fixation 09/2016
1	Operative Time 01/2016
1	Fecal Microbiota Transplantation 02/2014
1	Precision Medicine 01/2014
1	Radiotherapy 01/2014
1	Negative-Pressure Wound Therapy 01/2012
1	Salvage Therapy 04/2007